I have the 5-button Microsoft Intellimouse with an extra button on each side.
I realized the two things I did most when I was animating was Rotate and Play so I put Rotate on the left and Play on the right. I love that and I like how the Intellimouse has the two extra buttons positioned. Using the center roller for Zoom and Move works by default and those are great also.
For some reason, since v18 came in, I've noticed that the mouse buttons don't do anything until after I've used the keyboard shortcuts for Rotate and Play for the first time in a session, then they work again.
I also am not sure of your question. Could you clarify?