Dan, one example of someone combining two tracks (mixing story plus some domain) in the area of software development is Bob Martin's the Craftsman series of articles. From that link, under the "By Topic" column click on "Craftsman".
Alternately, maybe one thing you could do is have two tracks ... one of game reviews, and one of story. They could tie in to each other, so if someone got interested in one, they could easily find and follow the other. You could even have references to each other; for example, have one person playing the game in the story-based track, and have someone the characters in the game review track make references to what is going on in the story-based track.
You have displayed a lot of talent and skill with this series so far. You seem to have a good aptitude for using A:M, along with other tools to create a finished product -- a show.
It's not easy to find a niche that can be profitable, and since I've never done that I don't have a lot of suggestions.
Regarding mental health -- we are all ticking time bombs in one way or another. The only suggestions I can think of: 1. Fake it until you make it. 2. Through it all, treat everyone with respect.