Where to start? But how are you to know what you're doing wrong as there's no obvious guidelines....so, here's the lowdown....again:
First thing to know is to click on a line and you will see at the cp there is a yellow handle. If a spline is continuous, this handle should have a square on both ends. Grabbing the squares and moving them(then press undo after) will indicate which direction the spline goes.
1) In one CP there should be only 4 lines coming out. Anything more or less will produce a crease. You can use 5 point patches and hooks to get around this problem. Study the models on the cd to see how to use these.
2) The 4 lines should equate to 2 splines. That means you have 2 continuous splines running through every CP. The splines should cross each other like so..... X.....and not like this......)(
3) From your model, it looks like the lines on the outside and around the mouth and eyes are made up of many small splines. These should be consolidated into longer continuous splines.
4) Reduce the number of splines in the face. In particular coming off the nose...this can be done with hooks.
5) Stitching a spline into an exising patch produces a spline that constrains to the patches orientation. So no "roughness" will occur from misplacing a cp.
That's enough for now.
I should say, this is a better first effort than any I made!